巨噬細胞清除劑 Clophosome氯弗松 

Clophosome-氯弗松（Clodronate Liposomes-氯膦酸二鈉脂質體）CAS號 22560-50-5
 
Formumax Scientific公司生產的系列產品Clophosome（氯弗松）和Clophosome-A（陰離子氯弗松）是目前市場上的用于高效巨噬細胞耗竭的氯膦酸二鈉脂質體。此組產品具有活性高、有效期長、使用方便、無菌無毒等諸多*性能。該劑型優(yōu)點包括高濃度，高包封率，不黏稠，無沉淀，易于注射。尤其是優(yōu)化后的配方保證此產品即使在冰箱中儲存數(shù)月后仍能保持其高活性和均勻無沉淀狀態(tài)。我們提供的6個月產品保質期比其他廠家的同類產品高出一倍以上。該組產品適用于多種給藥途徑，包括靜脈注射、皮下注射、氣管給藥和直接注射等。在單次靜脈注射或腹腔注射0.2ml Clophosome后自24小時起脾臟和肝臟中巨噬細胞耗竭可持續(xù)一周保持在80%以上。如果每4天注射一次，高效巨噬細胞耗竭可持續(xù)數(shù)周之久。Formumax Scientific公司*轉型產品Clophosome-A，除保持了Clophosome所有優(yōu)點之外，更使得單次注射后巨噬細胞耗竭率高達90%以上。深受廣大科研用戶的歡迎。此組產品是免疫學、腫瘤學和其他生物學領域*的科研工具。

Clophosome®-A- Clodronate Liposomes (Anionic)

Clophosome®-A, negatively-charged clodronate liposomes, offers superior efficiency of macrophage depletion. Clodronate molecules are encapsulated in LUV liposomes for superior activity, physical and chemical stability, and convenience of use. It is formulated to an exceptionally high clodronate/lipid ratio.  Free clodronate is cleaned out and the liposomal encapsulation efficiency of clodronate is more than 90%. Clophosome liposomes remain homogenous even after long term storage in fridge. It is not viscous and easy to inject even with fine needles. It is manufactured sterile for long term shelf-life. 

The product is suitable for dosing with various routes including intravenous, intraperitoneal, subcutaneous, intranasal, intratracheal and etc. We have achieved > 90% depletion in splenic macrophages (red pulp macrophages) 24 hours after a single 0.2 mL intravenous injection. A starting dose of 0.15-2 mL (i.v. or i.p.) for 20-25g animal body weight is recommended for good consistency in macrophage depletion. Optimization is recommended for specific applications.

巨噬細胞清除劑 Clophosome氯弗松 

Specifications

Product name: Clophosome®-A

Product code: F70101C-A

Active: clodronat disodium. CAS: 22560-50-5, 7 mg/mL

Lipid composition: phosphatidylglycerol, phosphatidylcholine and cholesterol

Bulk solution: phosphate buffered sucrose (20mM sodium phosphate, 10% sucrose), pH 7.0-7.5

Shelf-life: 6 months guaranteed for unopened vials