目錄:漠寶（廈門）生物科技有限公司>>免疫學(xué)>>內(nèi)毒素檢測和去除>> L00402ToxinEraser™ Endotoxin Removal Resin
| 供貨周期 | 一周 | 規(guī)格 | 1 ml Resin (Total 2 ml) |
|---|---|---|---|
| 貨號 | Removal Resin | 應(yīng)用領(lǐng)域 | 醫(yī)療衛(wèi)生,環(huán)保,食品/農(nóng)產(chǎn)品,生物產(chǎn)業(yè),制藥/生物制藥 |
| 主要用途 | 利用固定化的多粘菌素B來結(jié)合并清除溶液中的致熱原 |
The ToxinEraser™ Endotoxin Removal Resin utilizes immobilized polymixin B to bind and remove pyrogens from solution. The polymixins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymixin B neutralizes the biological activity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide.
Description
Lipopolysaccharide (LPS) is a bacterial endotoxin, and a major constituent of the cell walls of gram-negative bacteria. During gram-negative bacteremia or endotoxemia, LPS is the principal pathophysiological mediator by which bacteria can cause hypotension, organ failure, disseminated intravascular coagulation, and fatal shock in mammalian hosts. The removal of these endotoxins is highly necessary for downstream processes.
The ToxinEraser™ Endotoxin Removal Resin utilizes immobilized polymixin B to bind and remove pyrogens from solution. The polymixins are a family of antibiotics that contain a cationic cyclopeptide with a fatty acid chain. Polymixin B neutralizes the biological activity of endotoxins by binding to the lipid A portion of bacterial lipopolysaccharide.
產(chǎn)品概述
Product Information
Binding Capacity： Up to 2,000,000 EU/ml resin.
Ligand： Modified PMB (Polymixin B)
pH Stability： pH 5 -10
Support Matrix ：4% cross-linked agarose, spherical beads
Mean Particle Size ：90 μm
Types of substances that can be applied to the column ：Protein, including peptides and antibody, polysaccharide, etc.
Applicable Ionic Strength ：0.1 to 0.5 M NaCl
Substances tested that do not interfere with performance： 20% DMSO, 20% ethanol, 20% glycerol; 1 M urea, 300 mM imidazole; 0.05% Tween 20, 10 mM DTT, etc.
Key Features
High stability and high removal efficiency.
High binding capacity: > 2, 000, 000 EU / ml (CV).
Reusable up to five times if properly regenerated.
產(chǎn)品屬性
Storage & Stability ：2°C to 8°C (Do not freeze.)
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