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基因點(diǎn)突變細(xì)胞，對(duì)于疾病的預(yù)測、研究與治療都能夠發(fā)揮作用。例如點(diǎn)突變細(xì)胞株可用于神經(jīng)疾病變性機(jī)制研究，小分子藥物研發(fā)，腫瘤診斷與治療，遺傳性疾病診斷登。除此之外，還有基因點(diǎn)突變載體構(gòu)建的相關(guān)服務(wù)，感興趣的話請前往進(jìn)行查詢。
Generation of Human Isogenic Induced Pluripotent Stem Cell Lines with CRISPR Prime Editing
Structural basis for pegRNA-guided reverse transcription by a prime editor
A truncated reverse transcriptase enhances prime editing by split AAV vectors
Structural basis for pegRNA-guided reverse transcription by a prime editor
Ex vivo prime editing of patient haematopoietic stem cells rescues sickle-cell disease phenotypes after engraftment in mice
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