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Palmitic acid

品牌：MedChemExpress (MCE)

貨號：HY-N0830

CAS：57-10-3

中文名稱：棕櫚酸

Synonyms：棕櫚酸

純度：99.76%

存儲條件：室溫保存

運輸條件：美國大陸的室溫；其他地方可能有所不同。

產(chǎn)品活性：Palmitic acid 是一種常見于動物和植物中的長鏈飽和脂肪酸。Palmitic acid 可以誘導小鼠顆粒細胞中葡萄糖調節(jié)蛋白 78 (GRP78) 和 CCAAT/增強子結合蛋白同源蛋白 (CHOP) 的表達。棕櫚酸鈉可以用于建立細胞脂肪變性模型。

生物活性：棕櫚酸是一種長鏈飽和脂肪酸，常見于動植物中。 PA 可誘導小鼠顆粒細胞中葡萄糖調節(jié)蛋白 78 (GRP78) 和 CCAAT/增強子結合蛋白同源蛋白 (CHOP) 的表達^{[1] [2]}。

IC50 & Target：Microbial Metabolite Human Endogenous Metabolite

參考文獻：

[1]. Harada H, et al. Antitumor activity of palmitic acid found as a selective cytotoxic substance in a marine red alga. Anticancer Res. 2002 Sep-Oct;22(5):2587-90.
[2]. Wen-Jin Ding, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22(3):1702-1708.
[3]. Liaqat H, et al. Antioxidant Effect of Wheat Germ Extracts and Their Antilipidemic Effect in Palmitic Acid-Induced Steatosis in HepG2 and 3T3-L1 Cells. Foods. 2021 May 12;10(5):1061.
[4]. Jiang H, et al. Palmitic acid promotes endothelial progenitor cells apoptosis via p38 and JNK mitogen-activated protein kinase pathways. Atherosclerosis. 2010 May;210(1):71-7.
[5]. Ding WJ, et al. Expression of Notch family is altered in non alcoholic fatty liver disease. Mol Med Rep. 2020 Sep;22(3):1702-1708.
[6]. Urso CJ, et al. Palmitic Acid Lipotoxicity in Microglia Cells Is Ameliorated by Unsaturated Fatty Acids. Int J Mol Sci. 2021 Aug 23;22(16):9093.
[7]. Wu D, et al. Palmitic acid exerts pro-inflammatory effects on vascular smooth muscle cells by inducing the expression of C-reactive protein, inducible nitric oxide synthase and tumor necrosis factor-α. Int J Mol Med. 2014 Dec;34(6):1706-12.